How the stimulation of follicles occurs in egg donors

In the context of the development of assisted reproductive technologies, an environmentally friendly and safe approach becomes increasingly important, especially when it comes to surrogacy. This issue is also relevant in the context of surrogacy in Cyprus (url), where surrogacy services are becoming available not only to traditional families but also to gay couples wishing to become parents. One of the key stages in the surrogacy process is the stimulation of follicles in the egg donor.

Follicle stimulation in egg donors is a medical procedure aimed at increasing the number of maturing eggs in the donor's ovaries within a single menstrual cycle. This process is part of assisted reproductive technology (ART) programs, such as IVF (in vitro fertilization) and surrogacy, helping to increase the chances of successful fertilization and obtaining healthy embryos for subsequent implantation.

In a normal menstrual cycle, a woman typically matures one egg. However, for ART needs, several eggs are often required to increase the likelihood of successful conception. In this case, the egg donor is prescribed special hormonal drugs that stimulate the ovaries to produce several eggs in one cycle.

The stimulation process includes several stages: Preparation: Before starting stimulation, the donor undergoes thorough medical examination to ensure there are no contraindications to the procedure. This also helps determine the optimal stimulation scheme for each specific case.

Ovarian stimulation: The donor is prescribed hormonal drugs (most often follicle-stimulating hormone, FSH), which accelerate the growth and maturation of eggs. The duration of stimulation and the dosage of the drugs are individually adjusted.

Monitoring: During stimulation, regular ultrasound of the ovaries and blood hormone tests are carried out to monitor the growth of follicles and adjust the dosage of drugs if necessary.

Ovarian puncture to extract eggs: Once the eggs reach maturity, a puncture of the ovaries is performed under local anesthesia to extract mature oocytes for their subsequent use within the IVF procedure. This process is minimally invasive and causes minimal trauma, performed using local anesthesia. The procedure typically takes about 15 minutes, after which the donor is allowed to go home. It is critically important for the donor to avoid eating and drinking directly before the procedure, which helps reduce potential risks and increase the efficiency of the manipulation.

In anticipation of the follicle puncture procedure, the donor is recommended to follow several important instructions to ensure maximum safety and effectiveness of the intervention. At these preparation stages, the key aspect is creating optimal conditions for the procedure and recovery afterward.

Preparation on the eve of the procedure: It is recommended to finish eating by 6:00 PM the evening before the puncture and to refrain from consuming liquids after midnight. These measures aim to minimize risks during anesthesia and simplify the recovery process.

Day of the procedure: It is important to refrain from eating and drinking until the puncture begins. This provides additional safety and reduces possible complications during and after the procedure.

Personal belongings: the donor is advised to avoid using makeup before going to the center, as well as to remove contact lenses and jewellery. This leads to infections or impediments to center staff when collecting the donor’s blood through her puncture.


Two hours after the donation has successfully ended, the donor remains under the staff’s control. This time is necessary to conclude that the donor’s condition is stable and she has fully recovered from the anesthesia. Likewise, the donor will have to speak to a physician regularly, checking that she feels good and is fully awake after all of the anesthesia.


It is then time to get up and slowly return to the rhythm of the usual life.


After this procedure, the patient can return to their normal state of hydration and diet, and there is no reason why they cannot maintain normal activities or well-being. For women with fertility problems due to poor-quality oocytes, donor eggs offer them the chance to trying the joy of motherhood. This procedure increases the chance of achieving successful fertilization and reduces teh risk of genetic disease and miscarriage, and in this way it enables a couple to start a family with a child that is biologically related to of the partners. Oocyte donation is a generous gesture that involves some young, healthy women who voluntarily to help other to have more chance of having a baby.


Frequently Asked Questions:

Question: How does the presence of 5 follicles in the ovaries affect pregnancy?

Answer: Discovering five follicles in the ovaries during the early stages of the menstrual cycle is a hopeful sign for those dreaming of motherhood through IVF. It indicates optimistic prospects for ovulation stimulation, highlighting that even with a low level of anti-Müllerian hormone (0.1 ng/ml), you have every chance of success.

Question: How many eggs can be expected after hormonal stimulation?

Answer: At the age of 32, thanks to hormonal stimulation, a woman can anticipate the maturation of 15 to 20 eggs. Of these, approximately 10 to 14 can be successfully fertilized, and 4-8 embryos will be ready for further development.

Question: What does the presence of two dominant follicles predict?

Answer: Finding two dominant follicles on an ultrasound can pleasantly surprise those dreaming of a large family, indicating the possibility of conceiving twins. These follicles, visible from the 7th day of the cycle, symbolize the start of a new path to possible double joy.

Question: What is the follicular reserve in women at 40 years old?

Answer: With age, by 40 years, the ovarian reserve naturally decreases to 5–10 thousand oocytes, continuing to offer chances for motherhood. This reminds us of the value of every moment on the path to realizing family dreams.

Question: Why is it critically important to drink plenty of water during stimulation?

Answer: Increased water intake during ovarian stimulation plays a key role in preventing ovarian hyperstimulation syndrome, ensuring comfort and safety of the process. It's a simple, yet powerful way to care for your health and well-being.

Question: How long does the ovarian stimulation process take?

Answer: The ovarian stimulation process, starting in the early days of the menstrual cycle, lasts from 7 to 12 days. Adhering to a precise medication schedule is critically important for achieving the best results, emphasizing the importance of discipline and attentiveness at every step of this path.